Daniel J. Campbell, Ph.D.

Daniel J. Campbell, Ph.D.

Member, Benaroya Research Institute and Affiliate Professor, Immunology

Dr. Campbell received his PhD in Molecular and Cell Biology at the University of California, Berkeley in 1998. Following a postdoctoral fellowship at Stanford, he joined the Benaroya Research Institute as Assistant Member in 2003.

Contact Info

Benaroya Research Institute at Virginia Mason
1201 Ninth Avenue
Seattle, WA 98101-2795
Phone: 206-341-1055
Fax: 206-233-7543

Research Areas

  • Tolerance & Autoimmunity
    Molecular Immunology

LAB

Benaroya Research

Pubmed

Daniel J. Campbell

The cells and tissues of the immune system are precisely organized to ensure the proper development, activation, function and regulation of diverse lymphocyte populations. Tissue and microenvironment selective lymphocyte homing is the basis for this organization, which in turn is mediated by lymphocyte expression of specific combinations of surface adhesion and chemoattractant receptors. Expression of these homing receptors therefore defines functionally specialized lymphocyte populations with unique tissue-tropisms.

We are interested in further exploring the relationship between lymphocyte function, homeostasis and localization. Using mouse models of autoimmunity, our goals are to track the differentiation and localization of various homing receptor-defined populations of CD4+ T cells, and to determine how each of these contributes to the function and regulation of immune responses in specific tissues. In addition, we seek to understand the signaling events and transcriptional networks that direct T cell expression of different homing receptor combinations, and therefore control ‘organ-specific' immunity and autoimmunity. Our work promises to yield new insights into lymphocyte differentiation and function, and holds great potential for the therapeutic manipulation of lymphocyte responses in the context of chronic infection, autoimmunity and transplantation.

The Campbell Laboratory is taking students at this time.

1. Campbell DJ, Koch MA. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol. 2011 Feb;11(2):119-30. Review.

2. Wesley JD, Sather BD, Perdue NR, Ziegler SF, Campbell DJ. Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice. J Immunol. 2010 Oct 15;185(8):4760-8. Epub 2010 Sep 20.

B.S., Chemistry, University of Michigan
Ph.D., Molecular and Cell Biology, University of California, Berkeley

Graduate Students
Kate Smigiel, ksmigiel@uw.edu
Shivani Srivastava, shivanis@uw.edu
Mike Stolley, stolleym@uw.edu

Postdoctoral Fellows
Mark Singh, msingh@benaroyaresearch.org

Laboratory Staff
Kerri Thomas, kthomas@benaroyaresearch.org
Thomas Duhen, Staff Scientist, tduhen@benaroyaresearch.org