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Estelle Bettelli, Ph.D.
Estelle Bettelli, Ph.D.
Associate Member, Benaroya Research Institute at Virginia Mason and Affiliate Associate Professor, Immunology
Dr. Bettelli received her PhD in Blood Cell Biology and Immunology at the University of Paris 7 in 2001. Following a postdoctoral training at the Brigham and Women’s Hospital, she became an Assistant Professor at the Brigham and Women's Hospital and Harvard Medical School, Boston. She joined the Benaroya Research Institute as an Assistant Member in 2009.
Benaroya Research Institute at Virginia Mason
1201 Ninth Avenue
Seattle, WA 98101-2795
Dr. Bettelli has studied T cells, which induce and regulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. CD4+ T helper cells can differentiate in different subsets characterized by specific effector functions and cytokine production. Th17 cells promote inflammation and have been implicated in the pathogenesis of many experimental autoimmune diseases and human inflammatory conditions. I have been one of the pioneers in the field of Th17 cell development and identified the factors, which are critical for the differentiation of pathogenic Th17 cells. I am currently studying the underlying mechanisms that govern the generation and functions of IL-17 producing T cells (Th17) and developing strategies to block their functions. Using mice lacking IL-23, Th17 effector cytokines, and Th17 specific genes, we seek to determine how Th17 responses are modulated and how the development of EAE can be inhibited. These studies will provide valuable insights into IL-17 and Th17 functions, and should help to design more specific therapies for the treatment of autoimmune diseases such as MS. As an assistant professor at Harvard Medical School and affiliated assistant professor at the University of Washington, I had the opportunity to train and mentored several pre and post-doctoral candidates. My work has been seminal in defining the factor important for the differentiation of a new subset of T helper cells called Th17.
.Mitsdoerffer M, Lee Y, Jager A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E*, and Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14292-7. *corresponding authors (PMID: 20660725) (PMC2922571)
M.S., CelleUniversite Pierre et Marie Curie
Ph.D., Blood Cell Biology, Universite Denis Diderot