Jarrod Dudakov, Ph.D.

Jarrod Dudakov, Ph.D.

Assistant Member, Fred Hutchinson Cancer Research Center, Affiliate Assistant Professor, Department of Immunology

Dr. Jarrod Dudakov earned his PhD  in Immunology and Stem Cell Biology at Monash University, in Melbourne, Australia, then studied as a Postdoctoral Fellow in Immunology at the Memorial Sloan Kettering Cancer Center, in New York. Currently, Dr. Dudakov is an Assistant Member at the Fred Hutchinson Cancer Research Center and an Affiliate Assistant Professor of Immunology at the University of Washington. 

Contact Info

Research Areas

  • Adaptive Immunity
    Developmental Immunology
    Regenerative Medicine

LAB

Open Lab Positons

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NCBI MyBibliography

Research

Thymopoiesis (T cell development) is a complex process involving crosstalk between developing thymocytes and the supporting stromal microenvironment, which is comprised of endothelial cells (ECs), fibroblasts, macrophages, dendritic cells (DCs), and highly specialized thymic epithelial cells (TECs). The result of these interactions is the generation of a T cell repertoire with an astounding breadth of diversity that enables the clearance of foreign pathogens.

Despite its importance, the thymus is exquisitely sensitive to acute injury such as that caused by infection, stress, or common cancer therapies such as cytoreductive chemo- or radiation therapy such as that used for successful hematopoietic cell transplantation (HSCT). However, the thymus also has a remarkable capacity for repair, although failure in these endogenous regenerative processes is a significant clinical problem that can facilitate cancer relapse, precipitate high morbidity and mortality from opportunistic infections, and lead to poor response to new vaccines. This is primarily because thymic regenerative capacity diminishes considerably with age and remains poorly understood. Hence a significant clinical challenge is the need for rapid regeneration of thymopoiesis following induced immunodepletion and transplantation.

The focus of the Dudakov Lab is to understand the processes underlying endogenous thymic regeneration so that they may be exploited into innovative clinical approaches to enhance T cell immunity in recipients of allo-HSCT and also for individuals with T cell deficiencies due to aging, autoimmune diseases, genetic causes, infectious disease, shock, radiation injury and common cytoreductive cancer treatments.

Publications

  1. Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL and van den Brink MRM. Interleukin-22 drives endogenous thymic regeneration in mice. (2012) Science. 336:91-95. Published online 1 March 2012. (DOI:1126/science.1218004)
  2. Tsai JJ, Dudakov JA, Takahashi K, Shieh JH, Singer NV, West ML, Smith OM, Young LF, Holland AM, Shono Y, Ghosh A, Tran HT, Moore MA and van den Brink MRM. Nrf2 regulates hematopoietic stem cell function. (2013) Nat Cell Biol. 15:309-316. Published online February 24th, 2013.
  3. Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VWC, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA* and van den Brink MRM*. Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. (2014). Exp. Med. 211:2341-2349. * Co-senior author
  4. Dudakov JA, Hanash AM and van den Brink MRM. Interleukin-22: Immunobiology and pathology. (2015). Annual Rev. Immunol. 33:747-785
  5. Khong DKM*, Dudakov JA*, Hammett MV, Goldberg GL, Ueno T, Jurblum MI, Spyroglou L, Young LF, van den Brink MRM, Boyd RL, and Chidgey AP. Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade. (2015) Stem Cell Reports. 4:445-458 *co-first author
  6. Dudakov JA, Mertelsmann A, O’Connor MH, Jenq RR, Velardi E, Young LF, Kreines F, Levy E, Smith OM, Boyd RL, van den Brink MRM and Hanash AM. Loss of innate lymphoid cells leads to impaired thymopoiesis in graft versus host disease. (In Press) Blood.

Education

  • A. (Politics), Monash University, Melbourne, Australia
  • Sc. (Hons.) (Immunology), Monash University, Melbourne, Australia
  • PhD (Immunology and Stem Cell Biology), Monash University, Melbourne, Australia
  • Postdoctoral (Immunology), Memorial Sloan Kettering Cancer Center, NY

 Lab members