Anthony Rongvaux, Ph.D.

Anthony Rongvaux, Ph.D.

Assistant Member, Fred Hutch, Affiliate Assistant Professor, Department of Immunology

Anthony earned his PhD from the Free University of Brussels, Belgium, in 2004. Currently, an Assistant Member in the Clinical Research Division, Program in Immunology, at the Fred Hutchinson Cancer Research Center, Dr. Rongvaux joined the Department of Immunology as an Affiliate Assistant Professor in September, 2017. 

Contact Info

Phone:(206) 667-7753

Fax: (206) 667-7983

FHCRC Mail Stop: D3-100

Research Areas

  • Cancer Biology
    Cell Death
    Macrophages
    Innate Immunity

LAB

Rongvaux Lab

Pubmed

Anthony Rongvaux, PhD

The Rongvaux Lab studies the innate immune response, the very first steps in the development of an immune response after exposure to a pathogen or formation of a tumor. Our work focuses on understanding how this immune system recognizes and responds to the presence of abnormal cells, such as tumors or infected cells, and how this immune response contributes to disease.

In particular, we are studying:

  1. How dying cells interact with the immune system and affect the outcome of the response, and
  2. How macrophages contribute to the tumor microenvironment and affect tumor development.

To address these questions, we are developing specific models of genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.

  1. Rongvaux A. Innate immunity and tolerance toward mitochondria. Mitochondrion.
    2017 Oct 17. pii: S1567-7249(17)30235-0. doi: 10.1016/j.mito.2017.10.007. [Epub
    ahead of print] Review. PubMed PMID: 29054471.
  2. Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B,
    Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA.
    Apoptotic caspases prevent the induction of type I interferons by mitochondrial
    DNA. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. PubMed
    PMID: 25525875; PubMed Central PMCID: PMC4272443.
  3. Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito
    Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Development and function
    of human innate immune cells in a humanized mouse model. Nat Biotechnol. 2014
    Apr;32(4):364-72. doi: 10.1038/nbt.2858. Epub 2014 Mar 16. PubMed PMID: 24633240;
    PubMed Central PMCID: PMC4017589.
  4. Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.
    Human hemato-lymphoid system mice: current use and future potential for medicine.
    Annu Rev Immunol. 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921.
    Epub 2013 Jan 16. Review. PubMed PMID: 23330956; PubMed Central PMCID:
    PMC4120191.
  5. Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ,
    Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human
    thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc
    Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83. doi: 10.1073/pnas.1019524108.
    Epub 2011 Jan 24. PubMed PMID: 21262827; PubMed Central PMCID: PMC3038726.

PhD (Free University of Brussels, 2004)

Lab Members

Trisha Sippel, Post-doctoral research fellow, tsippel@fredhutch.org
Sandra Oluoch, Research Technician, soluoch@fredhutch.org