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Pamela J. Fink, Ph.D.
Pamela J. Fink, Ph.D.
Dr. Fink graduated with a B.S. from Indiana University and received her Ph.D. in Biology from Massachusetts Institute of Technology in 1981. Her postdoctoral training was at Stanford University School of Medicine and the University of California, San Diego. She joined the University of Washington faculty in 1990. Dr. Fink is the current Editor-in-Chief of The Journal of Immunology, the flagship journal of The American Association of Immunologists.
Department of Immunology
University of Washington
Office E-471, Box 358059
750 Republican St.
Seattle WA 98109-8059
Our work is focused on the analysis of recent thymic emigrants (the youngest peripheral T cells) from mice carrying a transgene for green fluorescent protein driven by the RAG2 promoter. Our work has shown that T cells complete both functional and phenotypic maturation in the lymphoid periphery, a process driven by factors other than those that control T cell homeostasis and survival. Our work suggests the purpose of post-thymic T cell maturation is to expose young T cells to antigens expressed only outside the thymus, during a tolerance-prone transitional phase of development. Current work is centered on interrogating the environmental cues (such as the inflammatory milieu) that tune this tolerance process and to develop a model to test the involvement of recent thymic emigrants (including neonatal T cells) in tumor rejection.
1. Hendricks, D.W. and P.J. Fink. 2011. Recent thymic emigrants are biased against the Th1 and toward the Th2 effector lineage. Blood 117:139-1249. PMCID: PMC3056472
2. Hale, J.S., L.T. Nelson, K.B. Simmons, and P.J. Fink. 2011. Bcl-2-interacting mediator of cell death influences autoantigen-driven deletion and TCR revision. J. Immunol. 186:799-06. PMCID: PMC3233758
3. Houston, E.G., Jr., L.E. Higdon, and P.J. Fink. 2011. Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool. Proc. Natl. Acad. Sci USA 108:5366-5371. PMCID: PMC3069187
4. Fink, P.J. and D.W. Hendricks. 2011. Post-thymic maturation: young T cells assert their individuality. Nature Rev. Immunol. 11:544-549. PMCID: PMC3241610
5. Simmons, K.B.1, M. Wubeshet1, K.T. Ames, C.J. McMahan, J.S. Hale, and P.J. Fink. 2012. Modulation of TCRβ surface expression during TCR revision. (1: authors contributed equally) Cell. Immunol. 272:124-129. PMCID: PMC3244515
6. Houston, E.G. Jr., T.E. Boursalian, and P.J. Fink. 2012. Homeostatic signals do not drive post-thymic T cell maturation. Cell. Immunol. 274:39-45. PMCID: PMC3334402
7. Martins, V., E. Ruggiero, S.M. Schlenner, V. Madan, M. Schmidt, P.J. Fink, C. von Kalle, and H.R. Rodewald. 2012. Thymus-autonomous T cell development in the absence of progenitor import. J. Exp. Med. 209:1409-1417. PMCID: PMC3420332
8. Fink, P.J. 2013. The biology of recent thymic emigrants. Annu. Rev. Immunol. 31:31-50.
9. Vanden Driessche, K., A. Persson, B.J. Marais, P.J. Fink, and K.B. Urdahl. 2013. Immune vulnerability of infants to tuberculosis. Clin. Devel. Immunol. Article ID 781320; http://dx.doi.org/10.1155/2013/781320 (link is external)
10. Berkley, A.M.1, D.W. Hendricks1, K.B. Simmons, and P.J. Fink. 2013. Recent thymic emigrants and mature naïve T cells exhibit differential DNA methylation at key cytokine loci. (1: authors contributed equally) J. Immunol. 190:6180-6186. PMCID: PMC3679312
11. Higdon, L.E., K.A. Deets, T.J. Friesen, K.Y. Sze, and P.J. Fink. 2014. Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal center interactions. Proc. Natl. Acad. Sci. USA 111:5652-5657. PMCID: PMC3992682
12. Berkley, A.M. and P.J. Fink. 2014. Cutting Edge: CD8+ recent thymic emigrants exhibit increased responses to low affinity ligands and improved access to peripheral sites of inflammation. J. Immunol. 193:3262-3266. PMCID: PMC4170019
13. Philip, M., S.A. Funkhouser, E.Y. Chiu, S.R. Phelps, J.J. Delrow, J. Cox, P.J. Fink, and J.L. Abkowitz. 2015. Heme exporter FLVCR is required for T cell development and peripheral survival. J. Immunol. 194:1677-1685. PMCID: PMC4323866
14. Moguche, A.O., S. Shafiani, C. Clemons, R.P. Larson, C. Dinh, L.E. Higdon, C.J. Cambier, J.R. Sissons, A.M. Gallegos, P.J. Fink, and K.B. Urdahl. 2015. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. J. Exp. Med. 212:715-728. PMCID: PMC4419347
B.S., Biological Sciences, Indiana University
Ph.D., Biology, Massachusetts Institute of Technology