Research

UW Immunology faculty are internationally recognized for innovative and significant contributions to research in diverse areas of immunology.   

Our faculty are regularly published in the most competitive biomedical journals, and serve on the editorial boards for a number of these journals.  Faculty have an outstanding record of obtaining research funding; many faculty members are recipients of NIH MERIT Awards and prestigious junior faculty awards from the Cancer Research Institute, Burroughs Wellcome, Pew and Seale Scholars Programs.

TOLERANCE & AUTOIMMUNITY

Tolerance and autoimmunity includes the study of how the immune system distinguishes microbial products from self-antigens and how a breakdown in this process causes autoimmune disease. 

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ALLERGY

Allergy includes the study of hypersensitivity disorders of the immune system to normally innocuous environmental antigens.

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INNATE IMMUNITY

The study of innate immunity is focused on host defense mechanisms that sense the presence of pathogens in order to mobilize the immune response without requiring specific recognition of a particular pathogen.  Innate immune cells also play a role in tissue homeostasis and wound healing.

The Center for Innate Immunity and Immune Disease (CIIID) at the School of Medicine, directed by Dr. Michael Gale, Jr., focuses on innate immunity, which represents the body’s processes of immune recognition and response programming that establishes effective immunity and immune regulation. CIIID's mission is to provide a formal infrastructure for innate immunity research, development, and training activity that does not currently exist at the UW.

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ADAPTIVE IMMUNE RESPONSES

The study of the adaptive arm of the immune system focuses on the biology of lymphocytes that express unique receptors for specific antigens.  These lymphocytes are able to adapt the immune system to respond more efficiently to subsequent encounters with pathogens producing a specific antigen.  

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CANCER IMMUNOLOGY

Cancer immunology is the study of interactions between the immune system and cancer cells, including the focus on cancer-specific antigens with goals towards new vaccines and antibody therapies.

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DEVELOPMENTAL IMMUNOLOGY

Developmental immunology focuses on the generation of all components of the immune system during development of the organism.

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MOLECULAR IMMUNOLOGY

Molecular immunology focuses on molecular mechanisms that are involved in generating and regulating immune responses.  This area includes research on transcriptional, post-transcriptional, epigenetic and post-translational mechanisms for regulating expression of genes involved in immune responses, molecular mechanisms by which pathogens evade immune responses, signal transduction mechanisms in innate and adaptive immune cells that regulate their differentiation and function and molecular mechanisms that orchestrate the trafficking of immune cells and development of lymphoid organs.  

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