Roland K. Strong, Ph.D.

Roland K. Strong, Ph.D.

Full Member, Fred Hutchinson Cancer Research Center; and Affiliate Professor, Immunology

Dr. Strong received his Bachelor’s degree in Biophysics from the University of Michigan in 1984. After completing his Ph.D. in Biophysics at Harvard in 1990, Dr. Strong completed is post-doctoral training at the California Institute of Technology. He is a Member in the Division of Basic Sciences, Fred Hutchinson Cancer Research Center.

Contact Info

Fred Hutchinson Cancer Research Center
Division of Basic Sciences
Mail Stop A-025
1100 Fairview Avenue, N.
Seattle, WA 98109 
Phone: 206-667-5587
Fax: 206-667-7730

Research Areas

  • Molecular Immunology
    Innate Immunity

LAB

Strong Lab at FHCRC

Pubmed

Roland Strong at PubMed

Structural molecular immunology, vaccinology & translational biophysics: using biophysical approaches to study NK, T, and B cell receptors, understand immunorecognition of siderophores, further prophylactic and therapeutic vaccine development, and engineer targeted immunotheranostics (see lab link, above, for a current description of active projects).

1.  Allred, B. E., Rupert, P. B., Gauny, S. S., An, D. D., Ralston, C. Y., Sturzbecher-Hoehne, M., Strong, R. K., & Abergel, R. J. (2015) ‘Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides’ Proceedings of the National Academy of Sciences USA 112, pp. 10342-7

2. Finton, K. A. K., Friend, D., Jaffe, J., Gewe, M., Holmes, M. A., Larman, H. B., Stuart, A., Larimore, K., Greenberg, P. D., Elledge, S. J., Stamatatos, L. & Strong, R. K. (2014) ‘Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10’ PLoS Pathogens 10, pp. e1004403

3. Correia, B. E., Bates, J. T., Loomis, R. J., Baneyx, G., Carrico, C., Jardine, J. G., Rupert, R., Correnti, C., Kalyuzhniy, O., Vittal, V., Connell, M. J., Stevens, E., Schroeter, A., Chen, M., MacPherson, S., Serra, A. M., Holmes, M. A., Adachi, Y., Li, Y., Klevit, R. E., Graham, B. S., Wyatt, R. T., Baker, D., Strong, R. K., Crowe, J. E., Jr., Johnson, P. R. & Schief, W. R. (2014) ‘Proof of principle for epitope-focused vaccine design’ Nature 507, pp. 201-6

4. Finton, K. A. K., Larimore, K., Larman, H. B., Friend, D., Correnti, C., Rupert, P. B., Elledge, S. J.,  Greenberg, P. D. & Strong, R. K. (2013) ‘Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10’ PLoS Pathogens 9, e1003639

5. Allred, B. E, Correnti, C., Clifton, M. C., Strong, R. K. & Raymond, K. N. (2013) ‘Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae’ ACS Chemical Biology 8, pp. 1882-7

6. Davenport TM, Friend D, Ellingson K, Xu H, Caldwell Z, Sellhorn G, Kraft Z, Strong RK, Stamatatos L. Binding Interactions between Soluble HIV Envelope Glycoproteins and Quaternary-Structure-Specific Monoclonal Antibodies PG9 and PG16. J Virol. 2011 Jul;85(14):7095-107. Epub 2011 May 4. PMID:21543501

7. Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T, Strong RK. Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2414-9. Epub 2011 Jan 24.

8. Correia BE, Ban YE, Holmes MA, Xu H, Ellingson K, Kraft Z, Carrico C, Boni E, Sather DN, Zenobia C, Burke KY, Bradley-Hewitt T, Bruhn-Johannsen JF, Kalyuzhniy O, Baker D, Strong RK, Stamatatos L, Schief WR. Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure. 2010 Sep 8;18(9):1116-26.

9. Lu C, Xu H, Ranjith-Kumar CT, Brooks MT, Hou TY, Hu F, Herr AB, Strong RK, Kao CC, Li P. The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure. 2010 Aug 11;18(8):1032-43. Epub 2010 Jul 15.

10. Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol. 2010 Aug;6(8):602-9. Epub 2010 Jun 27.

B.S., Biophysics, University of Michigan
Ph.D., Biophysics, Harvard University

Graduate Students
James Jaffe, jaffej2@uw.edu

Postdoctoral Fellows
Kathryn Finton, kfinton@gmail.com
Mesfin Gewe, mesfing@uw.edu
Michelle Cook Sangar, mcooksan@fhcrc.org

Laboratory Staff
Della Friend, dfriend@fhcrc.org
Peter Rupert, prupert@fhcrc.org