Publication: Study reveals how cells work to keep inflammation in check

Finding about protein antagonists' activity may inform treatments for wide variety of disorders

Dr. Chrissy Lim (photo by Dr. Ram Savan)Researcher Chrissie Lim develops a test to examine strength of IL-22 signaling in the presence of human IL-22 binding proteins.

Ram Savan, Ph.D. A new study by University of Washington researchers reveals how cells keep inflammation in check by secreting protein antagonists that bind to and block inflammatory signals from white cells. The findings should help scientists to better understand and develop more effective treatments for a wide variety of inflammatory disorders. “Our findings show how cells use these binding proteins to act as a kind of rheostat that can fine-tune the inflammatory response,” said Ram Savan, a UW assistant professor of immunology, who led the research.

The results of the study appear today in Science Signaling. Lead researcher Ram Savan, a UW assistant professor of immunology. The researchers focused on proteins that block a signaling protein, interleukin-22, or IL-22, which is released by immune cells called lymphocytes. Depending on where in the body IL-22 is secreted, it can have protective effects on the skin, digestive tract, lungs and liver.

Read the full Health Sciences article here.

Photo: Ram Savan

Health Sciences Newsbeat Article By Michael McCarthy Updated 10:15 AM, 09.27.2016